Established 2019 · Series B · AI × Biomedical

Capital for
the inflection
point.

Spidal Venture partners with Series B founders building defensible companies where artificial intelligence and biomedical science converge — and compound.

$240M AUM
240M
Assets under management
27
Portfolio companies
B
Stage focus
18mo
Avg. follow-on

§ Thesis

The next decade of value will be created where computation meets cellular biology.

We invest at Series B — the moment a company has proven its science and product, and now needs disciplined capital to scale across markets, regulation, and infrastructure. This is where conviction is rewarded.

Our partners come from operating roles at frontier AI labs, oncology pipelines, and medical device pioneers. We bring more than capital: we bring the network that compresses the next five years of distribution into eighteen months.

Where we invest.

01

Foundation Models for Biology

Protein design, single-cell transcriptomics, and multi-modal models trained on proprietary lab data.

02

Clinical Intelligence

AI systems that augment diagnosticians, radiologists, and pathologists with regulatory-grade evidence.

03

Drug Discovery Platforms

End-to-end pipelines where machine learning compresses preclinical timelines by orders of magnitude.

04

Medical Devices & Robotics

Embedded intelligence at the point of care — surgical robotics, wearables, and decentralized trials.

§ Selected Portfolio

Founders building the durable companies of the decade.

Helion Therapeutics
Generative protein design
2023
Lead
Nimbus Diagnostics
Multi-modal oncology AI
2022
Co-lead
Axon Robotics
Autonomous surgical assistants
2024
Participant
Caelum Bio
Foundation model for transcriptomics
2023
Lead
Polaris Trials
Decentralized clinical infrastructure
2024
Lead
Vesper Health
Closed-loop neural implants
2022
Co-lead

From the partnership

"We don't chase narratives. We underwrite the founders who will still be compounding when the cycle turns."
— Managing Partners, Spidal Venture

§ Get in touch

Building
something
extraordinary?

We read every introduction. The most useful pitches arrive with a working product, a defensible insight, and a clear question.

Limited Partners
lp@spidalventure.com
Offices

Menlo Park · Boston · London